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Pharmacology
Department of Pharmacology

About the Department

Department of Pharmacology offers two years post graduate programme in Pharmacology and Doctoral degree affiliated to The TN Dr. MGR Medical University, Chennai. The students joining M. Pharm Pharmacology will be capable of screening the drugs for Pharmacological activity and efficacy, Drug design and Development, Clinical Research and Toxicological sciences. The students have career in the pharmaceutical industries in preclinical testing, toxicology, clinical research or in new drug development. The candidate can take research as his/her career.

Faculty Details
Professor and Head
  • Dr. M Ramanathan (Principal)
Assistant Professors
  • Mr. G. Venkatesh
  • Mr. K. Ragavan
  • Ms. Anila Kumar
  • Mr. A. Tamilselvan
Research Scholars
  • Mr. B Darshit Shah
  • Mr. R. Ranjith
  • Mr. S. Diwakar’
  • Mr. Mrinmoy Gautam
Facilities

Laboratory

  • Central and In house Animal Facility
  • Pharmacology Research Lab
  • In vitro Cell Culture
  • Molecular Pharmacology Lab
  • Molecular Modeling Lab
  • Histopathology lab
Equipments & Infrastructure

Molecular Pharmacology

  • Western blot
  • Real Time-PCR
  • Gel Electrophoresis
  • Multiplate reader
  • Inverted Trinocular Phase Contrast Microscope
  • Fluorescence Inverted Microscope
  • CO2 Incubator
  • Deep Freezer (-80oC)
  • Refrigerated Centrifuge
  • Laminar Airflow
  • Autoclave Sterilizer
  • Deep Freezer (-20°C)
  • Ice machine

Behavioural pharmacology

  • Water maze
  • Rotarod
  • Pole Climbing Apparatus
  • Actophotometer
  • Basic equipments to assess the behaviour of the animals
  • Stereotaxic apparatus
  • Laser Doppler Imager
  • Surgical microscope
  • Grip strength

Analgesic Responses

  • Hot plate
  • Paw pressure meter
  • Plethysmometer
  • Analgesiometer
  • Cell Counter
  • Auto Analyzer
  • High Performance Thin Layer Chromatography
  • Electrical Analytical Balance
  • Central Instrumentation facilities (UV, HPLC, UPLC)
  • Von Frey apparatus
  • Tail flick apparatus

Cardiovascular pharmacology

  • 4 Channel Physiograph
  • Non-invasive BP apparatus

Drug Design and Development

  • Schrödinger – GLIDE, QIKPROP, PHASE, STRIKE, CANVAS
  • Molecular Dynamics: GROMACS
  • Machine Learning Algorithms: WEKA

Histopathology lab

  • Microtome
  • Tissue processing unit
  • Tissue embedder with cold plate

Conferences Organized – 2

Workshop conducted – 3

Invited Lectures – 25

Awards and Honours

Dr. M. Ramanathan received Professional Excellence Award from The Tamilnadu Dr. MGR Medical University, Chennai on reorganization of service rendered to Pharmacy profession 2011

Papers presented in the conferences – 56

Papers published in the peer reviewed journals – 53

Funded projects for total worth Rs 1.53 crores

  • Department of Science and Technology -2
  • Department of Biotechnology – 2
  • Indian Council of Forestry and Research Education – 1
  • Tamil Nadu Pharmaceutical Welfare Trust – 2
Research and Development

Funded projects for total worth more than Rs 2 crores

Ongoing Projects

Principal

 Investigator

Title of Project

Funding Agency

Amount

(in lakhs)

Dr. M. Ramanathan

Elucidation of neuroprotective mechanism of angiotensin in middle cerebral artery occluded rat model

ICMR

41.00

Dr. M. Ramanathan

Development and Elucidation of mechanism of action of some herbs to treat diabetic neuropathic pain

DBT

(2014-2015)

10.51

Dr. M. Ramanathan

Preclinical evaluation of modified estrogen receptor beta agonists for prostate cancer treatment

DST-SERB

(2012-2015)

30.12

Dr. M. Ramanathan

Androgen receptor mediated drug development to treat Prostate Cancer

DBT-NE Twinning

(2012-2015)

46.12

Projects Completed

Principal Investigator

Title of Project

Funding Agency

Amount

(in lakhs)

Dr. M. Ramanathan Development of glycogen synthase kinase-3β inhibitors for neurogenesis in neurodegenerative disorders DBT(2011-2014)

66.11

Dr. M. Ramanathan Phytochemical, Pharmacological and toxicological investigation of Aegle Marmelos for a new product ICFRE

13.43

Dr. M. Ramanathan Standardization, validation and development of herbal formulation for the treatment of neuropathic pain DST-DPRP(2008-2011)

51.20

Dr. M. Ramanathan Glabridin derivatives for the estrogen receptor b mediated growth control of the prostate cancer cells DST-SERC(2008-2011)

20.99

Awarded project to Students
  • Mr. R  Ranjith kumar [Research Scholar]  visited Medicinal and Biological Chemistry department of University of Toledo USA , During the period of May 15 to July. 15,2014. (Visiting Research Faculty award by University of Toledo  5000 USD)
  • Ms. Kalpana Eluri [II M. Pharm] got a student project worth Rs. 8000 for the year 2010-11 from the Tamilnadu Pharmaceutical Sciences Welfare Trust. Mr. KG Prasanth is the Research Supervisor for the work entitled “Evaluation of the effect of tetrahydrocurcumin in HMG-CoA reductase and lipoprotein lipase enzymes in high fat diet induced hypercholesteremia in rabbits”
  • Mr. Ranjith Kumar [II M. Pharm] got a student project worth Rs. 7000 for the year 2010-11 from the Tamilnadu Pharmaceutical Sciences Welfare Trust. Mr. B Balaji is the Research Supervisor of this project entitled “Evaluation of mechanism of action of Nerunjil in neuropathic pain perception in experimentally induced diabetic model”
Thrust area

Dr. M Ramanathan

  • Neuroprotective drugs development through understanding the mechanism under lying neuroinflammation and neurogenesis

Mr. KG Prasanth

  • Screening of drug for diabetic and its complication, atherosclerosis and evaluating the role of free radicals and inflammatory mediators in the pathophysiology of diabetic complications.

Mrs. C Kalaiyarasi

  • Neurobehavioral research involving screening the drugs for antidepressant, anticonvulsant, anxiolytic, learning, memory and exploring the role of neurotransmitters

Mr. B Prem Kumar

  • Clinical research focusing diabetes, dentistry, rheumatic musculoskeletal disorders including pharmacovigilance

Mr. B Balaji

  • Designing and screening of new chemical molecules for the treatment of prostate cancer targeting nuclear receptors

Linkages with Industry and R & D Labs

  1. Stempeutics Research Pvt Ltd., Bangalore
  2. Sami Labs (P) Ltd., Bangalore
  3. University of Toledo, Ohio state, USA
  4. Arya Vaidya Nilayam (P) Ltd., Madurai
  5. Arya Vaidyasala (P) Ltd., Coimbatore
  6. Department of Biotechnology, PSG College of Technology, Coimbatore
  7. Department of Chemistry, Annamalai University, Chidambaram
  8. Central Forest Research Institute, Coimbatore
  9. Department of Biological and Chemical Sciences, Guwahati
  10. Department of Pharmacology, Manipal College of Pharmaceutical Sciences

 

Products developed

 

Principal Investigator: Dr. M. Ramanathan

  • Perment capsules (consists of concentrated aqueous extracts of Bacopa monnieri, Withania somnifera, Asparagus racemosa and Clitoria ternatea)

Indications: Perment is used as an adaptogenic agent for the treatment of sub clinical anxiety and depression.

  • Evaluation of different combinations of herbal extracts/formulations for diabetic neuropathic pain
  • Isoflavone based new chemical entities have been developed targeting estrogen receptor beta for prostate cancer  “Therapeutic Benefits of Novel Daidzein Analogues In Estrogen-Associated Disorders” Ref No./Application No.- 1667/CHE/2013
  • A phytoproduct “R-500” (Aegle marmelos capsules) for antidepressant and anxiolytic properties from Aegle marmelos fruit has been developed with due pharmacological and toxicological evaluation